High-throughput biointerfaces for direct, label-free, and multiplexed metaplasmonic biosensing

In recent years, metaplasmonic biosensors have emerged as a novel counterpart of well-established plasmonic based on thin metallic layers. Metaplasmonic offer high potential for sensor miniaturization, extreme sensitivity biosensing, and multiplexing capabilities with detection methods free coupling optical elements. These make highly attractive Point-of-Care handled/portable devices or On-Chip devices; result, it has increased the number prototypes applications that during last years. One main challenges to achieving fully operative is achievement high-throughput biointerfaces sensitive selective biodetection in complex media. Despite superior surface achieved by sensors compared conventional films, limitations multiplexed biosensing usually are associated selectivity biointerface and, consequence, their application direct analysis real samples. This graphical review discusses different biofunctionalization strategies, biorecognition elements, antifouling strategies achieve scalable bioengineering like Organs-On-Chip.